Eyes in the Ocean
Artist: Raymond S.
Artwork Description:
The figure submerged in deep water symbolizes life under the constant pull of an inescapable fate. The large head and sunken skinportray key features of Gorlin Syndrome; indeed, the figure pulls one of eye out represents the cross-eyed symptom of Gorlin Syndrome. At the same time, the luminous gaze represents the inner strength of patients living within the quiet depth of their struggles.


Disease Introduction: Gorlin Syndrome (Nevoid Basal Cell Carcinoma Syndrome)
Type: Genetic tumor predisposition disorder
Affected Organs: Skin, skeletal system, nervous system

Symptoms:
Multiple basal cell carcinomas appearing in adolescence or early adulthood. Characteristic facial features such as macrocephaly, frontal bossing, and wide-set eyes. Jaw cysts causing facial swelling and dental abnormalities. Palm and sole pits, rib anomalies, scoliosis, and occasionally developmental delay or medulloblastoma in children. Sensitivity to ultraviolet light increases cancer risk.

Cause / Risk Factors:
Mutations in the PTCH1 gene, a critical regulator of the Hedgehog signaling pathway, lead to uncontrolled cellular proliferation and tumor formation. Inheritance follows an autosomal dominant pattern, though new mutations are common.

Treatments:
Frequent dermatologic surveillance and early excision of basal cell carcinomas are essential.
Laser ablation, cryotherapy, or photodynamic therapy may manage multiple lesions.
Targeted therapy with Hedgehog pathway inhibitors such as vismodegib or sonidegib can reduce tumor burden in advanced cases.
Dental and skeletal abnormalities may require maxillofacial surgery.
Sun protection and avoidance of radiation exposure are critical preventive strategies.